BROMELAIN
Written by Slawomir (“Swavak”) Gromadzki, MPH
WHAT IS BROMELAIN
Bromelain is a type of proteolytic (helps brake down proteins) enzymes, found in pineapple fruit (especially in stems or cores). Bromelain is composed of several endopeptidases and compounds like peroxidase, phosphatase, glucosidase, escharase cellulase, and protease inhibitors. It is a powerful digestive aid effective in the entire digestive system including in the presence of stomach acid and also in the alkaline environment of the intestines. The activity of Bromelain is measured in GDUs (Gelatin Digesting Units) which indicate the proteolytic (protein digesting) activity.
Pineapple is not only a rich source of enzyme bromelain, but also potassium, manganese vitamin C, vitamin B, and phytonutrients.
USES
– According to over 1,600 scientific papers attempting to evaluate the health benefits of bromelain, it can be beneficial in addressing the following health problems:
– Digestive problems including indigestion, heartburn, diarrhoea, etc.
– Osteoarthritis, rheumatoid arthritis, & joint pain
– Cellulite
– Deep vein thrombosis (DVT) & blood clots
– Inflammatory bowel disease (IBD)
– Bronchitis and sinusitis
– Allergies, Hay fever (allergic rhinitis) & Asthma
– Autoimmune diseases
– Overweight
– Cardiovascular disorders
– Cancer
– Connective tissue injuries
– Sprained ankles
– Tendonitis
– Wounds or burns (to speed up healing) (Avoid taking Bromelain immediately after surgery without consulting it with your doctor, as Bromelain reduces blood clotting and therefore may increase bleeding!)
– Blocked Fallopian Tubes (together with Serrapeptase)
– Poor absorption of drugs, especially antibiotics
– Liver problems
– Malaria
– Inner thigh discolouration (dark inner thighs)
KEY HEALTH BENEFITS
ARTHRITIS
Due to its powerful analgesic (painkilling) and anti-inflammatory properties, Bromelain can be very effective as a natural painkiller (it works even better when it is used alternatively with Serrapeptase). According to one study, a group of participants with osteoarthritis were given capsules with 650 mg of Bromelain two to three times a day on an empty stomach. As a result, the inflammation and pain were reduced by up to 60%! (>)
DIGESTIVE PROBLEMS
Bromelain is effective against various digestive and gastrointestinal problems simply because it is an enzyme that helps to digest proteins. It also supports absorption of nutrients. It is known to ease colon inflammation and symptoms of autoimmune inflammatory bowel disease by reducing secretion of pro-inflammatory cytokines which damage the gut lining.
Due to the fact that Bromelain actually heals the gastrointestinal tract lining, it is beneficial for the following GI problems:
– Inflammatory bowel disease (Ulcerative colitis & Crohn’s disease)
– Heartburn
– Colon cancer
– Dyspepsia
– Gastric ulcers (caused by helicobacter pylori)
– Constipation and Diarrhoea
ALLERGIES & ASTHMA
It has been known for a long time that Bromelain can help reduce symptoms of allergy, hay fever or asthma including runny nose, itchy eyes, or difficulty breathing. The key cause of allergies, asthma is oversensitivity of human immune system which triggers immune reaction and release of histamine when there is no need to do so. We know that this strange behaviour has a lot to do with stress, anxiety, low mood and depression, deficiency of vitamin D, zinc, selenium magnesium, and overconsumption of heated animal protein. However, it was found that also in this case Bromelain may be very helpful because it can positively modulate the immune system, reduce its oversensitivity, decrease allergic reactions and even stop inflammatory responses of the immune system that affect the airways. According to certain study, a specific type of dendritic cells and antigen-presenting cells of the immune system were not overreacting and causing asthma or allergies in participants who were on Bromelain.
SINUSITIS (RHINO SINUSITIS)
According to one study 12 patients sinusitis were treated with a daily dose of 600-milligram Bromelain (300 FIP units) for three months. As a result the participants reported significant improvement of improved symptoms with no adverse effects.
“I was getting a cold & lots of sinus pressure. I took 1 500 mg tablet of bromelain 3x a day and did wonders. No sinus headache and slept perfectly thru the night. The bromelain allowed everything in my head to drain.”
DEEP VEIN THROMBOSIS (DVT) & PULMONARY EMBOLISM (PE)
Bromelain increases prothrombin time (PT), which helps prevent coagulation (blood clotting) and therefore can be beneficial in preventing Pulmonary Embolism in people with Deep Vein Thrombosis (DVT). However, if you are on blood thinning medication such as warfarin you must consult your doctor about supplementing with bromelain and for dosage recommendation, because using Bromelain together with medication may thing the blood too much and increase risk of internal bleeding.
Several studies gave evidence that bromelain may stop blood platelets from forming clots inside the body, which can minimize the impacts of severe blood vessel, circulatory, heart and brain conditions in which clotting can lead to a problem. (>)
WEIGHT LOSS
Bromelain also seems to help with weight loss due to its ability to down-regulate adipocyte fatty acid-binding protein, lipoprotein lipase and fatty acid synthase. It also helps maintaining normal body weight by reducing triglyceride (type of body fat) accumulation and inhibiting adipogenesis (cell differentiation that can contribute to formation of fat cells).
INFLAMMATION & PAIN
Since Bromelain has anti-inflammatory properties it can be used to reduce inflammation and pain. For instance, according to one study Bromelain was able to sooth pain, decrease swelling and inflammation, and enhanced wound healing after tooth extractions. Participants of the study who were on bromelain reported significantly lower post-operation inflammation, swelling and pain compared to the control group treated with painkillers.
SPORT INJURIES
Bromelain may speed up healing time after a physical or sport injury. It results in reduced swelling from sprains, strains, bruises, and other minor muscle injuries.
VARICOSE VEINS AND HAEMORRHOIDS
Because it has positive effects on swelling, irritation, and wound healing, bromelain can be used to soothe haemorrhoids and varicose veins.
FOOD SOURCE OF BROMELAIN
The best by far source of Bromelain is fresh (not canned) Pineapple (especially the core). Try to buy a soft and ripe fruit or wait till it is soft, because the riper it is, the softer the core will be. Eat the fruit and use the core to make a juice or a smoothie together with raw organic carrots and spinach to boost the healing properties of the juice or smoothie. Keep in mind that juice will have much higher concentration of active ingredients (including Bromelain) than smoothie and it’s easier to ingest due to lack of fibre.
SUPPLEMENTS
If you are trying to improve digestion you should take bromelain supplements with meals, but for all other health problems take it on an empty stomach.
SUGGESTED DOSAGES
– Arthritis: 2-3 times a day 500 mg
– Allergies and Asthma: 2 times a day 500 mg plus Quercetin (to lower histamine)
– Cancer: 2 times a day 1,000 mg plus other Proteolytic enzymes
– Digestive problems: 3 times 500 mg with meals
– After surgery (to speed up recovery): 3 times a day 1,000 mg
Remember that Bromelain should always be taken on an empty stomach. Only in case of digestive problems or to improve digestion you should take it with meals.
CONTRAINDICATIONS
– Avoid taking Bromelain immediately after surgery without consulting it with your doctor, as Bromelain reduces blood clotting and therefore may increase bleeding!
– Bromelain is very unlikely to cause side effects. However, since it helps prevent blood clots, it is important to consult your physician if you are on blood-thinning medications.
– Remember that Bromelain may also increase absorption of antibiotics and other medications.
UNITS OF MEASUREMENT
Bromelain enzymatic activity can be measured in various ways. The listed below different units express the activity level of the enzyme; the higher the number, the more active it is.
– Gelatine digesting units (GDU/gram)
– FIP units (amount that hydrolyzes casein)
– Casein Digestion Units (CDU/mg)
– PU (Papain Units)
– Milk clotting units (MCU)
– Rorer units (RU)
– Bromelain Tyrosine Units (BTU/ gram)
SOURCES
– https://draxe.com/6-unbelievable-health-benefits-bromelain/
– https://www.globalhealingcenter.com/natural-health/bromelain/
– https://www.ncbi.nlm.nih.gov/pubmed/23570457
– https://www.sciencedirect.com/science/article/pii/S095980491400519X
– https://www.ncbi.nlm.nih.gov/m/pubmed/18160345/
– https://www.ncbi.nlm.nih.gov/pubmed/15936249
– https://www.ncbi.nlm.nih.gov/pubmed/28217537
– https://www.ncbi.nlm.nih.gov/pmc/articles/PMC538506/
– https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3870104/
– https://www.ncbi.nlm.nih.gov/pubmed/24273953
– Pavan R, et al. “Properties and Therapeutic Application of Bromelain: A Review.” Biotechnol Res Int. 2012; 2012,976203.
– Brien S, et al. “Bromelain as an adjunctive treatment for moderate-to-severe osteoarthritis of the knee: a randomized placebo-controlled pilot study.” QJM. 2006;99(12),841-50.
– Rathnavelu V, et al. “Potential role of bromelain in clinical and therapeutic applications.” Biomed Rep. 2016;5(3),283–288.
– Onken JE, et al. “Bromelain treatment decreases secretion of pro-inflammatory cytokines and chemokines by colon biopsies in vitro.” Clinical Immunology. 2008;126(3),345–352.
– Chandler DS, Mynott TL. “Bromelain protects piglets from diarrhoea caused by oral challenge with K88 positive enterotoxigenic Escherichia coli.” Gut. 1998;43(2),196-202.
– Eckert K, et al. “Effects of oral bromelain administration on the impaired immunocytotoxicity of mononuclear cells from mammary tumor patients.” Oncol Rep. 1999;6(6),1191-9.
– Desser L, et al. “Cytokine synthesis in human peripheral blood mononuclear cells after oral administration of polyenzyme preparations.” Oncology. 1993;50(6),403-7.
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