QUERCETIN
Written by Slawomir Gromadzki, MPH
WHAT IS QUERCETIN
Quercetin is a flavonoid (plant pigment) commonly found especially in onions, apples and citrus fruits.
ANTIOXIDANT
It is a potent antioxidant that fights against free radicals.
COVID AID
Evidence suggests hydroxychloroquine works for COVID-19 because it acts as a zinc ionophore, meaning it shuttles zinc inside your cells. Also Quercetin (500mg-1000mg twice daily) works as zinc ionophore and therefore magnifies antiviral effects of zinc.
Quercetin (500mg-1000mg twice daily) helps to increase the intracellular concentrations of Zinc by transporting it through the cell membrane. The major benefit of taking Quercetin with Zinc is that the quercetin will push the zinc into the center of the cell where the zinc can stop the virus from reproducing. Combination of Zinc with Quercetin has been found to be one of the most effective treatments against covid. “Antiviral Effects of Quercetin through Zinc Ionophore (ion carrier) Activity” (>). Quercetin is an increasingly well-known plant compound with potent anti-inflammatory effects. The SARS-CoV-2 outbreak resulted in renewed research efforts focusing on its effects as a zinc-ionophore, increasing intracellular zinc concentrations and thus Quercetin working as an antiviral. Preliminary studies in South Korea and China have pointed to Quercetin’s potential for inhibiting viral replication of SARS-CoV-2. In a 2014 publication, researchers demonstrated clearly that quercetin and a similar polyphenol (epigallocatechin-gallate) were capable of rapidly increasing zinc concentrations in Hepa 1-6 cells and liposomes. The mechanism of action was found to be independent of plasma membrane zinc transporters.[>]. A 2016 study examined fourteen polyphenols – including Quercetin – and their capacity to form complexes with zinc cations. The results confirmed that polyphenols have the capacity to transport zinc across a variety of lipid membranes [>].
ANTI-STRESS REMEDY
Quercetin can reduce cortisol release during times of extended stress.
CARDIOVASCULAR HEALTH
It improves blood circulation, promotes normal blood pressure and protects against LDL cholesterol oxidation.
METABOLISM & WEIGHT MANAGEMENT
Few studies also demonstrated Quercetin improves metabolism helping to control body weight.
ANTI-CANCER
and may have potent anticancer properties with regards to prostate and colon cancer.
ALLERGY & ASTHMA
Quercetin helps easy allergies as it has an antihistamine properties. When our respiratory system is irritated, inflamed and swollen, it is the result of the release of histamine hormone, and since quercetin has an antihistamine affect it provides relief for those who experience common infection or allergy symptoms such as runny nose, inflammation and swelling.
According to a 2000 report from Alternative Medicine Review quercetin can slow up the release of histamines (chemical released by the immune system during exposure to allergens causing allergy symptoms including itching, sneezing, runny nose, and watery eyes).
Also an animal-based study published in 2007 indicates that quercetin can lower histamine and inflammation in allergies.
A study with guinea pigs demonstrated that quercetin was able to reduce airway hypersensitivity and relax the bronchial airways (>).
Quercetin exhibits the same anti-allergic potential as the Chinese Food Allergy Herbal Formula, which has been shown to block peanut anaphylaxis in mouse models (>). However since peanut allergy can be very dangerous, please do not try to use quercetin instead of medication.
According to a 2013 study Quercetin may have a bronchial dilating effect by reducing the release of proteins which lead to swelling and airway narrowing.
Quercetin will be a good candidate for the supplement on the management and treatment of allergic diseases
INTERACTIONS
Large amounts may interact with blood thinners, corticosteroids, and aspirin.
SOURCES & REFERENCES
Weng Z, Zhang B, Asadi S, Sismanopoulos N, Butcher A, Fu X, Katsarou-Katsari A, Antoniou C, Theoharides TC. Quercetin is more effective than cromolyn in blocking human mast cell cytokine release and inhibits contact dermatitis and photosensitivity in humans. PLoS One. 2012;7(3):e33805. doi: 10.1371/journal.pone.0033805. Epub 2012 Mar 28.
Townsend EA, Emala CW Sr. Quercetin acutely relaxes airway smooth muscle and potentiates-agonist induced relaxation via dual phosphodiesterase inhibition of PLC and PDE4. Am J Physiol Lung Cell Mol Physiol. 2013 Jul 19.
Chirumbolo S. The role of quercetin, flavonols and flavones in modulating inflammatory cell function. Inflamm Allergy Drug Targets. 2010 Sep;9(4):263-85.
Perez-Vizcaino F, Duarte J. Flavonols and cardiovascular disease. Mol Aspects Med. 2010 Dec;31(6):478-94. doi: 10.1016/j.mam.2010.09.002. Epub 2010 Sep 15.
Egert S, Bosy-Westphal A, Seiberl J, Kürbitz C, Settler U, Plachta-Danielzik S, Wagner AE, Frank J, Schrezenmeir J, Rimbach G, Wolffram S, Müller MJ. Quercetin reduces systolic blood pressure and plasma oxidised low-density lipoprotein concentrations in overweight subjects with a high-cardiovascular disease risk phenotype: a double-blinded, placebocontrolled cross-over study. Br J Nutr. 2009 Oct;102(7):1065-74. doi: 10.1017/S0007114509359127. Epub 2009 Apr 30.
Cheng LC, Li LA. Flavonoids exhibit diverse effects on CYP11B1 expression and cortisol synthesis. Toxicol Appl Pharmacol. 2012 Feb 1;258(3):343-50. doi: 10.1016/j.taap.2011.11.017. Epub 2011 Dec 8.
Wang G, Song L, Wang H, Xing N. Quercetin synergizes with 2-methoxyestradiol inhibiting cell growth and inducing apoptosis in human prostate cancer cells. Oncol Rep. 2013 Jul;30(1):357-63. doi: 10.3892/or.2013.2469. Epub 2013 May 15.
http://www.globalhealingcenter.com/natural-health/health-benefits-of-quercetin/
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